The Birthplace of Velázquez was built sometime between 1560 and 1570, in the heart of the Moorish quarter of Seville. In 1598 the married couple consisting of Juan Rodríguez de Silva, ecclesiastical notary, and Jerónima Velázquez went to live there and the following year had their first child, Diego Rodríguez de Silva y Velázquez.
Diego remained with his family until 1610, when at the age of 11 he began his apprenticeship as a painter, first for a few months with Herrera el Viejo, and then with Francisco Pacheco, with whom he completed his training over six years, being admitted in 1617 to the painters' guild and this is when he started his professional career.
The house remained as popular housing for four centuries, until in the 1970s it was refurbished and converted into an art gallery. In 1984, it was bought by Victorio y Lucchino, the Sevillian couturiers who converted it into their workshop until 2010 when it went into receivership. In 2018 a company purchased the house with the aim of preserving it and opening it to the public as a visitor centre dedicated to the life and work of the Sevillian painter. They are currently working on this project.