Located in La Puerta de Jerez, between Avenida de la Constitución and Calle San Gregorio, it is all that remains of the College-University founded by Maese Rodrigo de Santaella in 1506.
The chapel building is in the late Gothic-Mudejar style, with parts of it faced with exposed brick.
The building is currently owned by the University of Seville. A feature of this small chapel in the main altarpiece by Alejo Fernández, one of the most important artists working in the city at that time and whose works include a number of panels in the cathedral. It was completed by this German artist in 1520.
The dry cord, multi-coloured tile panels are another important feature.