Founded in 1353 as a convent of the Sancti Spiritu by one of the oldest orders that emerged in the Pontificate of Innocent II, who were dedicated to picking up sick and poor helpless elderly people. Since then several orders inhabited the convent, dedicating themselves to various activities always of a social nature, until in 1810 the Napoleonic troops occupied the building and looted it and in their flight in 1812, they set fire to the church which was almost sunk being able to save most of the artworks. Its rebuilding could be carried out thanks to a farmhouse and some goods that the religious of Sancti Spititu had left that had been reserved from the confiscation, with the contribution of their own money from the administrator and chaplain Don Álvaro Joaquín del Rosal y Estrada and others aid from the people.
After these works, the church was reduced to the disappearance of the old chapels, which currently have a neoclassical style. This new temple was inaugurated on January 1, 1817. Currently this church houses the Jesus Nazareno, whose author is Juan de Mesa (1622) in which he perfected his Nazarene version of the Great Sevillian Power. This church also contains the masonry altarpiece and dressing room of the image of Jesus Nazareno, the work of the 18th century master Francisco Ambrosio de León, as well as the magnificent altarpiece in imitation mahogany wood with carved gilt appliques and moldings of the Virgen de dressing room.
La Soledad, the work of the Ecijano sculptor Juan González, year 1778. Said altarpiece is made up of the central part that leads to the dressing room, and the lateral wings that open in which the void that had to have embedded a bas-relief carved in mahogany appears with motives of the Passion of Christ. These pieces would give the altarpiece an even greater value and of great merit that we believe would be stolen as a result of the fire by the French occupation.